Anne Comi, M.D.

Dr. Anne Comi
Anne Comi
Director, Hunter Nelson Sturge-Weber Center at Kennedy Krieger Institute

Kennedy Krieger Institute
801 N. Broadway
Baltimore, MD 21205

Anne Comi, MD, is the director of the Hunter Nelson Sturge-Weber Center and an Associate Professor in the Division of Neurology and Developmental Medicine at the Kennedy Krieger Institute and Johns Hopkins Medicine.

Biographical Sketch:

Dr. Comi is the director of the Hunter Nelson Sturge-Weber Center at Kennedy Krieger Institute. She graduated from SUNY Buffalo School of Medicine and received her training in pediatrics at the Children's Hospital of Buffalo and her child neurology training at Johns Hopkins Medicine. Her clinical specialization is in the treatment of the neurological aspects of Sturge-Weber syndrome and other capillary malformation related disorders.

Research Summary:

Her clinical research interests are focused on improving the early diagnosis and treatment of brain involvement in Sturge-Weber syndrome, in order to prevent ischemic brain injury in these infants and young children, and on studies to understand what causes Sturge-Weber syndrome. Her laboratory research work deals with the pathogenesis of Sturge-Weber syndrome recently shown to be caused by a somatic mutation and on developing new drug targets, screening assays, models and therapeutic strategies for Sturge-Weber syndrome. Her lab group also works on developing better neuroprotective and neuroregenerative responses to brain injury resulting from impaired blood flow to the brain.

LINK: SciVal Experts Research Profile for Anne Comi

Research Publications:

Comi AM. Pathophysiology of Sturge-Weber Syndrome. J. Child Neurol. 2003; 18 (8):509-516.

Comi AM, Kossoff EH, Fischer R. Encephalofacial angiomatosis sparing the occipital lobe and without facial nevus: on the spectrum of Sturge-Weber Syndrome variants? J. Child Neurol. 2003; 18 (1):35-38.  PMID:  12661936. 

Comi AM, Hunt P, Vawter MP, Pardo CA, Becker K, Pevsner J. Increased fibronectin expression in Sturge-Weber Syndrome Fibroblasts and Brain Tissue. Pediatr. Res. 2003; 53 (5):762-9.  PMID:  12621118.

 Lin DDM, Barker PB, Kraut MA, Comi AM. Early characteristics of Sturge-Weber syndrome on perfusion MR imaging and proton MR spectroscopic imaging.  Am. J Neuroradiol. 2003; 24(9):1912-5.  PMID:  14561628.

Comi AM, Weisz CJ, Highet BH, Johnston MV, Wilson MA. A new model of stroke and ischemic seizures in the immature mouse. Pediatr Neurol. 2004; 31(4):254-257.  PMID:  15464636. 

Comi AM, Johnston MV, Wilson MA. Immature mouse unilateral carotid ligation model of stroke. Special edition for United Cerebral Palsy Foundation sponsored meeting on animal models of cerebral palsy. J Child Neurol. 2005; 20(12):980-3.  PMID:  16417846.

Kossoff EH, Hatfield LA, Ball KL, Comi AM. Comorbidity of epilepsy and headache in patients with Sturge-Weber syndrome. J Child Neurol. J Child Neurol. 2005; 20(8):678-82.  PMID:  16225815.

Comi AM, Weisz CJ, Highet BH, Skolasky RL, Pardo CA, Hess EJ. Sturge-Weber syndrome: Altered blood vessel fibronectin expression and morphology. J Child Neurol. 2005; 20(7):572-7.  PMID:  16159522. 

Comi AM, Mehta P, Hatfield LA, and Dowling M. Sturge-Weber syndrome associated with other abnormalities: a medical record and literature review. Arch Neurol. 2005; 62(12):1924-7.  PMID:  16344352.

Kelley TM, Hatfield LA, Lin D, Comi AM. Quantitative analysis of cerebral cortical atrophy and correlation with clinical severity in unilateral Sturge-Weber syndrome. J Child Neurol. 2005; 20(11):867-70.  PMID:  16417855.

Comi AM, Johnston MV, Wilson MA. Strain variability, injury distribution and seizure onset in a mouse model of stroke in the immature brain. Dev Neurosc. 2005; 27 (2-4):127-133.  PMID:  16046846.

Comi, AM. Neuroprotection for Ischemic Injury in the Immature Brain Current Pediatric Reviews. Curr. Pediatr. Rev. 2005; 1 (2): 135-145.

Lin DM, Gailoud P, McCarthy E, Comi AM. Oromaxillofacial osseous abnormality in Sturge-Weber disease: case report and review of literature. Am J Neuroradiol. 2006; 27(2):274-7.  PMID:  16484391.

Miller RS, Ball K, Comi AM, Germain-Lee EL. Growth Hormone Deficiency in Children with Sturge-Weber Syndrome. Archives Disease of Childhood, 2006; 91(4):340-1.  PMID:  16551788.  PMCID:  PMC2065976.

Lin, DM, Barker PB, Hatfield L, Comi AMDynamic MR perfusion and proton MR  spectropscopy imaging in Sturge-Weber syndrome: correlation with neurological symptoms. J. Magn Reson Imaging. 2006; (2):274-81.  PMID:  16786573.

Comi, AM. Advances in Sturge-Weber Syndrome. Current Opinion in Neurology. 2006; 19(2):124-8. PMID: 16538084.

Comi AM, Highet BH, Mehta P, Chong TH, Johnston MV, Wilson MA. Dextromethorphan protects male but not female mice with brain ischemia.  Neuroreport, 2006;17(12):1319-22.  PMID:  19651577.

Ewen JB, Comi AM, Kossoff EH. Myoclonic-astatic epilepsy in a child with Sturge-Weber syndrome. Pediatric Neurology.  200; 36(2):115-7.  PMID:  17275664.

Comi AM. Update on Sturge-Weber Syndrome: Diagnosis, Treatment, Quantitative Measure, and Controversies.  Lymphatic Research and Biology 2007; 5(4):257-264.  PMID:  18370916.

Comi AM. Sturge-Weber syndrome and epilepsy: an argument for aggressive seizure management in these patients. Expert Rev. Neurotherapeutics 2007; 7(8): 951-956.  PMID:  17678489.

Hatfield LA, Crone NE, Kossoff EH, Pyzik PA, Lin DDM, Kelley TM, Comi AM. Quantitative EEG asymmetry correlates with clinical severity in unilateral Sturge-Weber syndrome. Epilepsia, 2007; 48(1):191-5.  PMID:  17241228.

Kossoff EH, Balasta M., Hatfield LM, Lehmann CU, Comi AM.  Self-reported treatment   patterns in patients with Sturge-Weber syndrome and migraines. J. Child Neurology. 2007; 22(6):720-6.  PMID:  17641257.

Jordan, LJ, Wityk RJ, Dowling MM, DeJong MR, Comi AMTranscranial Doppler Ultrasound in Children with Sturge-Weber Syndrome. J. Child. Neurol. 2008; 23 (2): 137-43.  PMID:  18056693.

Comi AM, Cho E, Mulholland J, Hooper A, Li Q, Qu Y, Gary D, McDonald J, Johnston MV. Neural stem cells reduce brain injury after unilateral carotid ligation. Pediatric Neurol. 2008; 38 (2): 86-92.  PMID:  18206788.

Kadam SD, Mulholland  JD, McDonald JW, Comi AM. Neurogenesis and neuronal commitment following ischemia in a new mouse model for neonatal stroke. Brain Res 2008; 7;1208:35-45. PMID:  18387598. PMCID:  PMC2525449.

Traa BS, Mulholland JD, Kadam SD, Johnston MV, Comi AM. Gabapentin Neuroprotection and Seizure Suppression in Immature Mouse Brain Ischemia. Pediatric Research. 2008;4(1):81-5.  PMID:  18391849.  PMCID: PMC2565570.

Comi AM, Bellamkonda S, Ferenc LM, Cohen BA, Germain-Lee. Central Hypothyroidism and Sturge-Weber Syndrome. Pediatr Neurol.  2008;39(1):58-62.  PMID:  18555176. 

Kadam SD, Mulholland JD, B.S, Smith DR, Johnston MV, Comi AMChronic brain injury and behavioral impairments in a mouse model of term neonatal strokes. Behav Brain Research 2009;30; 197(1):77-83.  PMID:  18761039.  PMCID:  PMC2607476.

Comi AM, Trescher WH, Abi-Raad R, Johnston MV, Wilson MA. Impact of age and strain on   ischemic brain injury and seizures after carotid ligation in immature mice.  Int J Dev Neurosci. 2009;27(3):271-7. PMID:  19154784.  PMCID:  PMC2652514.

Smith Pearl M, Abdalla WM, Lin DD, Comi AM, Boltshauser E, Gailloud P, Huisman TA.  Sturge-Weber syndrome with cerebellar involvement. J Neuroradiol. 2009;36(1):57-60. PMID:  18722014.

Reesman J, Gray R, Suskauer SJ, Ferenc LM, Kossoff EH, Lin DD, Turin E, Comi AM, Brice PJ, Zabel TA. Hemiparesis Is a Clinical Correlate of General Adaptive Dysfunction in Children and Adolescents With Sturge-Weber Syndrome. J Child Neurol.  2009;24(6):701-8. PMID:19359254.

Eric H. Kossoff, Lisa Ferenc, Anne M. Comi.  An infantile-onset, severe, yet sporadic seizure pattern is common in Sturge-Weber syndrome.  Epilepsia.  2009;50(9):2154-7. PMID:  19389148.

Kadam SD, Mulholland JD, McDonald JW, Comi AM.  Post-stroke subgranular and rostral subventricular zone proliferation in a mouse model of neonatal stroke. J Neuroscience Research, 2009;87(12):2653-66.  PMID:  19396874.

Ewen JB, Kossoff EH, Crone NE, Lakshmanan BM, Ferenc LM, Comi AM.  Use of Quantitative EEG in Infants with Port-Wine Birthmark to Assess for Sturge-Weber Brain Involvement. Clinical Neurophysiology, 2009;120(8):1433-40.  PMID:  19589723.  PMCID:  PMC2754702. 

Arulrajah S, Ertan G, Comi AM, Tekes A, Lin DL, Gailloud P, Huisman TAGM. Magnetic Resonance Imaging and Diffusion weighted imaging in Children with simultaneous supra and infratentorial manifestations of Sturge Weber Syndrome. J Neuroradiology.  2010;37(1):51-9.

Suskauer SJ, Trovato MK, Zabel TA, Comi AM. Physiatric findings in individuals with sturge-weber syndrome. Am J Phys Med Rehabil. 2010;89(4):323-30.  PMID: 20068437.

Zabel T, Reesman J, Wodka EL, Gray R, Suskauer SJ, Turin E, Ferenc LM, Lin DD, Kossoff EH, Comi, AMNeuropsychological Features and Risk Factors in Children with Sturge-Weber Syndrome: Four Case Reports. Clin Neuropsychol. 2010;24(5); 841-59. PMID:  20560093.

Quan SY, Comi AM, Parsa CF, Irving ND, Krakowski AC, Cohen BA. Effect of a single application of pulsed dye laser treatment of port-wine birthmarks on intraocular pressure.  Arch Dermatol. 2010; 146(9):1015-8.  PMID:  20855702.

Markowitz GJ, Kadam SJ, DM Boothe, Irving ND, Comi AM. The pharmacokinetics of commonly used antiepileptic drugs in immature CD1 mice. NeuroReport.  2010; 21;21(6):452-6.  PMID:  20848732.

Kadam SD, Smith-Hicks CL, Smith DR, Worley PF, Comi AM. Functional integration of new neurons into hippocampal networks and poststroke comorbidities following neonatal stroke in mice. Epilepsy Behav. 2010;18(4):344-57.  PMID:  20708575. 

Albéri L, Chi Z, Kadam SD, Mulholland JD, Dawson VL, Gaiano N, Comi AM. Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury. Stroke. 2010;41(10 Suppl):S64-71.  PMID:  20876509.  PMCID: PMC3034189.

Kossoff EH, Borsage JL, Comi AM. A pilot study of the modified Atkins diet for Sturge-Weber syndrome. Epilepsia 2010;92(2-3):240-3.  PMID: 20934305.

Turin E, Grados M, Tierney E, Ferenc L, Zabel A, Comi A. Behavioral and Psychiatric Features of Sturge-Weber Syndrome. J Nerv Ment Dis. 2010;198(12):905-13. PMID: 21135644.

Bay MJ, Kossoff EH, Lehmann CU,  Zabel AT, Comi AM. Survey of Aspirin Use in Sturge-Weber Syndrome. J Child Neurology. 2011 26(6):692-702. PMID: 21427442  

Comi A. Presentation, diagnosis, pathophysiology, and treatment of the neurological features of Sturge-Weber syndrome. The Neurologist. 2011. 17(4):179-84

Markowitz GJ, Kadam SD, Smith DR, Johnston MV, Comi AM. Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. Epilepsy Research, 2011 94(3): 138-148.  PMID 21481568

Warren Lo, Doug Marchuk, Karen Ball, Marsha Moses, Csaba Juhász, Joshua Ewen, Lori Jordan, Anne Comi and the Brain Vascular Malformation Consortium.  Updates and Future Horizons on the Understanding, Diagnosis and Treatment of Sturge-Weber Syndrome Brain Involvement. 2012. Developmental Medicine and Child Neurology. 54(3):214-23.

Kadam SD, Gucek M, Cole RN, Watkins PA, Comi AM. Cell proliferation and oxidative stress pathways are modified in fibroblasts from Sturge-Weber syndrome patients. Arch Derm Res. 2012. 304(3):229-35.

Lopez J, Yeom K, Comi A, Van Haren K. Case report of subdural hematoma in a patient with Sturge-Weber Syndrome and literature review: Questions and implications for therapy. J Child Neurol. Epub ahead of print.

Lance EI, Sreenivasan AK, Zabel A, Kossoff EH, Comi AM. Aspirin Use in Sturge-Weber Syndrome: Side Effects and Clinical Outcomes. Journal of Child Neurology. Epub ahead of print. 

Siddique L, Sreenivasan AK, Comi AM, Germain-Lee EL.  Importance of Utilizing a Sensitive Free T4 Assay in Sturge-Weber Syndrome. Journal of Child Neurology. 28(2):269-74. 

Falahati S, Breu M, Waickman AT, Phillips AW, Arauz EJ, Snyder S, Porambo M, Goeral K, Comi AM, Wilson MA, Johnston MV, Fatemi A. Ischemia-Induced Neuroinflammation Is Associated with Disrupted Development of Oligodendrocyte Progenitors in a Model of Periventricular  Leukomalacia. Dev Neuroscience. Epub ahead of print.

Karun SA, Quigley HA, Comi A, Rhonda BM, Jampel. Increased Choroidal Thickness in Patients with Sturge-Weber Syndrome. JAMA Opthalmology. In Press.

Sreenivasan A, Bachur C, Lanier K,Curatolo A, Connors S, Moses M*, Comi AM*.  Urine biomarkers in Sturge-Weber syndrome. Vascular Medicine. In Press. * Drs. Moses and Comi contributed equally to this manuscript.

Akers A, Ball KL, Clancy M, Comi AM, Faughnan ME, Gopal-Srivastava R, Jacobs TP, Kim H, Krischer J, Marchuk DA, McCulloch CE, Morrison L, Moses M,  Moy C, Pawlikowska L, Young WL, on behalf of the BVMC* Brain Vascular Malformation Consortium: Overview, Progress and Future Directions. Journal of Rare Diseases. In Press.

Shirley MD, Tang H, Gallione CJ, Baugher JD, Frelin LP, Cohen B, M.D., North PE, Marchuk DA,* Comi AM,* Pevsner J.* A GNAQ Somatic Mutation Causes Sturge-Weber Syndrome and Port-wine Stains.  New England J Medicine.  In press.*Drs. Marchuk, Comi and Pevsner contributed equally to this manuscript as senior authors.