Antibodies against fetal brain in sera of mothers with autistic children.

TitleAntibodies against fetal brain in sera of mothers with autistic children.
Publication TypeJournal Article
Year of Publication2008
AuthorsSinger HS, Morris CM, Gause CD, Gillin PK, Crawford S, Zimmerman AW
JournalJournal of neuroimmunology
Volume194
Issue1-2
Pagination165-72
Date Published2008 Feb
Abstract

Serum antibodies in 100 mothers of children with autistic disorder (MCAD) were compared to 100 age-matched mothers with unaffected children (MUC) using as antigenic substrates human and rodent fetal and adult brain tissues, GFAP, and MBP. MCAD had significantly more individuals with Western immunoblot bands at 36 kDa in human fetal and rodent embryonic brain tissue. The density of bands was greater in fetal brain at 61 kDa. MCAD plus developmental regression had greater reactivity against human fetal brain at 36 and 39 kDa. Data support a possible complex association between genetic/metabolic/environmental factors and the placental transfer of maternal antibodies in autism.

DOI10.1523/JNEUROSCI.4512-07.2008
Alternate JournalJ. Neuroimmunol.