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Artificial reporter gene providing MRI contrast based on proton exchange.
|Title||Artificial reporter gene providing MRI contrast based on proton exchange.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Gilad AA, McMahon MT, Walczak P, Winnard PT, Raman V, van Laarhoven HWM, Skoglund CM, Bulte JWM, van Zijl PCM|
|Date Published||2007 Feb|
Existing magnetic resonance reporter genes all rely on the presence of (super)paramagnetic substances and employ water relaxation to gain contrast. We designed a nonmetallic, biodegradable, lysine rich-protein (LRP) reporter, the prototype of a potential family of genetically engineered reporters expressing artificial proteins with frequency-selective contrast. This endogenous contrast, based on transfer of radiofrequency labeling from the reporter's amide protons to water protons, can be switched on and off.
|Alternate Journal||Nat. Biotechnol.|