Association of genetic variation in CACNA1C with bipolar disorder in Han Chinese.

TitleAssociation of genetic variation in CACNA1C with bipolar disorder in Han Chinese.
Publication TypeJournal Article
Year of Publication2013
AuthorsZhang X, Zhang C, Wu Z, Wang Z, Peng D, Chen J, Hong W, Yuan C, Li Z, Yu S, Fang Y
JournalJournal of affective disorders
Volume150
Issue2
Pagination261-5
Date Published2013 Sep 5
Abstract

A growing body of evidence highlights the existence of shared genetic susceptibility to both major depressive disorder (MDD) and bipolar disorder (BD), suggesting some potential genetic overlap between the disorders. Genome-wide association studies have identified consistent association of single nucleotide polymorphisms of the α-1 C subunit of the L-type voltage-gated calcium channel gene (CACNA1C) with MDD and BD, suggesting CACNA1C as a promising candidate gene for susceptibility to mood disorders. In the present study, we tested the association of CACNA1C with MDD and BD in Han Chinese.

DOI10.3978/j.issn.2225-319X.2013.07.23
Alternate JournalJ Affect Disord