Atlas-guided tract reconstruction for automated and comprehensive examination of the white matter anatomy.

TitleAtlas-guided tract reconstruction for automated and comprehensive examination of the white matter anatomy.
Publication TypeJournal Article
Year of Publication2010
AuthorsZhang Y, Zhang J, Oishi K, Faria AV, Jiang H, Li X, Akhter K, Rosa-Neto P, Pike BG, Evans A, Toga AW, Woods R, Mazziotta JC, Miller MI, van Zijl PCM, Mori S
JournalNeuroImage
Volume52
Issue4
Pagination1289-301
Date Published2010 Oct 1
Abstract

Tractography based on diffusion tensor imaging (DTI) is widely used to quantitatively analyze the status of the white matter anatomy in a tract-specific manner in many types of diseases. This approach, however, involves subjective judgment in the tract-editing process to extract only the tracts of interest. This process, usually performed by manual delineation of regions of interest, is also time-consuming, and certain tracts, especially the short cortico-cortical association fibers, are difficult to reconstruct. In this paper, we propose an automated approach for reconstruction of a large number of white matter tracts. In this approach, existing anatomical knowledge about tract trajectories (called the Template ROI Set or TRS) were stored in our DTI-based brain atlas with 130 three-dimensional anatomical segmentations, which were warped non-linearly to individual DTI data. We examined the degree of matching with manual results for selected fibers. We established 30 TRSs to reconstruct 30 prominent and previously well-described fibers. In addition, TRSs were developed to delineate 29 short association fibers that were found in all normal subjects examined in this paper (N=20). Probabilistic maps of the 59 tract trajectories were created from the normal subjects and were incorporated into our image analysis tool for automated tract-specific quantification.

DOI10.1016/j.neuroimage.2010.06.058
Alternate JournalNeuroimage