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Catalytic enantioselective synthesis of naturally occurring butenolides via hetero-allylic alkylation and ring closing metathesis.
|Title||Catalytic enantioselective synthesis of naturally occurring butenolides via hetero-allylic alkylation and ring closing metathesis.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Mao B, Geurts K, Fañanás-Mastral M, van Zijl AW, Fletcher SP, Minnaard AJ, Feringa BL|
|Date Published||2011 Mar 4|
An efficient catalytic asymmetric synthesis of chiral γ-butenolides was developed based on the hetero-allylic asymmetric alkylation (h-AAA) in combination with ring closing metathesis (RCM). The synthetic potential of the h-AAA-RCM protocol was illustrated with the facile synthesis of (-)-whiskey lactone, (-)-cognac lactone, (-)-nephrosteranic acid, and (-)-roccellaric acid.
|Alternate Journal||Org. Lett.|