Catalytic enantioselective synthesis of vicinal dialkyl arrays.

TitleCatalytic enantioselective synthesis of vicinal dialkyl arrays.
Publication TypeJournal Article
Year of Publication2008
Authorsvan Zijl AW, Szymanski W, López F, Minnaard AJ, Feringa BL
JournalThe Journal of organic chemistry
Volume73
Issue18
Pagination6994-7002
Date Published2008 Sep 19
Abstract

With a consecutive "asymmetric allylic alkylation (AAA)/cross-metathesis (CM)/conjugate addition (CA)" protocol it is possible to synthesize either stereoisomer of compounds containing a vicinal dialkyl array with excellent stereoselectivity. The versatility of this protocol in natural product synthesis is demonstrated in the preparation of the ant pheromones faranal and lasiol.

DOI10.1152/ajpcell.00277.2012
Alternate JournalJ. Org. Chem.