Chemoprevention of head and neck cancer by simultaneous blocking of epidermal growth factor receptor and cyclooxygenase-2 signaling pathways: preclinical and clinical studies.

TitleChemoprevention of head and neck cancer by simultaneous blocking of epidermal growth factor receptor and cyclooxygenase-2 signaling pathways: preclinical and clinical studies.
Publication TypeJournal Article
Year of Publication2013
AuthorsShin DM, Zhang H, Saba NF, Chen AY, Nannapaneni S, Amin RARM, Müller S, Lewis M, Sica G, Kono S, Brandes JC, Grist WJ, Moreno-Williams R, Beitler JJ, Thomas SM, Chen Z, Shin HJC, Grandis JR, Khuri FR, Chen ZG
JournalClinical cancer research : an official journal of the American Association for Cancer Research
Volume19
Issue5
Pagination1244-56
Date Published2013 Mar 1
Abstract

We investigated the efficacy and underlying molecular mechanism of a novel chemopreventive strategy combining EGF receptor (EGFR) tyrosine kinase inhibitor (TKI) with cyclooxygenase-2 inhibitor (COX-2I).

DOI10.1155/2013/591796
Alternate JournalClin. Cancer Res.