The combined treatment of venlafaxine and quetiapine for treatment-resistant depression: a clinical study.

TitleThe combined treatment of venlafaxine and quetiapine for treatment-resistant depression: a clinical study.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi X, Xing B, Yu E, Chen W, Wu H
JournalThe Journal of neuropsychiatry and clinical neurosciences
Volume25
Issue2
Pagination157-60
Date Published2013 Spring
Abstract

The authors studied the efficacy and safety of combined venlafaxine and quetiapine treatment for treatment-resistant depression (TRD) by dividing 95 TRD patients into two treatment groups: a combined venlafaxine (225 mg/day) and quetiapine (400 mg/day) group and a venlafaxine-only (225 mg/day) group for 8 weeks. Efficacy was assessed with the Hamilton Rating Scale for Depression, 17 items (Ham-D-17) and the Hamilton Rating Scale for Anxiety (Ham-A); safety was assessed with the Treatment-Emergent Symptom Scale (TESS). The two groups showed significant differences for the Ham-D-17 and Ham-A and no differences on the TESS. Combined venlafaxine and quetiapine treatment showed good efficacy and safety in TRD.

DOI10.1126/science.1236789
Alternate JournalJ Neuropsychiatry Clin Neurosci