Corpus callosum segment circumference is associated with response control in children with attention-deficit hyperactivity disorder (ADHD).

TitleCorpus callosum segment circumference is associated with response control in children with attention-deficit hyperactivity disorder (ADHD).
Publication TypeJournal Article
Year of Publication2010
AuthorsMcNally MA, Crocetti D, Mahone ME, Denckla MB, Suskauer SJ, Mostofsky SH
JournalJournal of child neurology
Volume25
Issue4
Pagination453-62
Date Published2010 Apr
Abstract

Response control is impaired in attention-deficit hyperactivity disorder (ADHD). Given the corpus callosum's role in response control, we compared callosal morphology in 64 children with ADHD and 64 typically developing children, aged 7 to 13 years, and investigated the relationships between callosal morphology and response control. Area and circumference of 5 callosal segments (genu, rostral body, midbody, isthmus, and splenium) were normalized for cerebral volume and examined for correlation with mean reaction time, intrasubject variability, and/or commission error rate from a go/no-go task. There were no between-group differences in segment areas or circumferences. Reaction time correlated with midbody circumference for boys with ADHD and isthmus circumference for girls with ADHD. For the entire cohort, rostral body circumference correlated with intrasubject variability. Impaired response control in ADHD is associated with anomalies in frontal interhemispheric connections. Future studies examining callosal shape will illuminate the anatomic basis of correlations between callosal segment circumference and response control.

DOI10.1177/0883073809350221
Alternate JournalJ. Child Neurol.