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Delayed neural network degeneration after neonatal hypoxia-ischemia.
|Title||Delayed neural network degeneration after neonatal hypoxia-ischemia.|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Authors||Stone BS, Zhang J, Mack DW, Mori S, Martin LJ, Northington FJ|
|Journal||Annals of neurology|
|Date Published||2008 Nov|
Clinical magnetic resonance studies show delayed and ongoing neurodegeneration after neonatal hypoxia-ischemia (HI), but the mechanisms and timing of this neurodegeneration remain unclear. We used ex vivo diffusion tensor imaging (DTI) and brain neuropathology to determine whether selective injury to white matter tracts occurs after neonatal HI in mice resulting in neural system-associated attrition in remote regions and at delayed times.
|Alternate Journal||Ann. Neurol.|