Delayed neural network degeneration after neonatal hypoxia-ischemia.

TitleDelayed neural network degeneration after neonatal hypoxia-ischemia.
Publication TypeJournal Article
Year of Publication2008
AuthorsStone BS, Zhang J, Mack DW, Mori S, Martin LJ, Northington FJ
JournalAnnals of neurology
Volume64
Issue5
Pagination535-46
Date Published2008 Nov
Abstract

Clinical magnetic resonance studies show delayed and ongoing neurodegeneration after neonatal hypoxia-ischemia (HI), but the mechanisms and timing of this neurodegeneration remain unclear. We used ex vivo diffusion tensor imaging (DTI) and brain neuropathology to determine whether selective injury to white matter tracts occurs after neonatal HI in mice resulting in neural system-associated attrition in remote regions and at delayed times.

DOI10.1002/ddrr.41
Alternate JournalAnn. Neurol.