Detection of amyloid plaques in mouse models of Alzheimer's disease by magnetic resonance imaging.

TitleDetection of amyloid plaques in mouse models of Alzheimer's disease by magnetic resonance imaging.
Publication TypeJournal Article
Year of Publication2004
AuthorsZhang J, Yarowsky P, Gordon MN, Di Carlo G, Munireddy S, van Zijl PCM, Mori S
JournalMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
Volume51
Issue3
Pagination452-7
Date Published2004 Mar
Abstract

We performed three-dimensional, high-resolution magnetic resonance imaging (MRI) of fixed mouse brains to determine whether MRI can detect amyloid plaques in transgenic mouse models of Alzheimer's disease. Plaque-like structures in the cortex and hippocampus could be clearly identified in T2-weighted images with an image resolution of 46 microm x 72 microm x 72 microm. The locations of plaques were confirmed in coregistration studies comparing MR images with Congo red-stained histological results. This technique is quantitative, less labor-intensive compared to histology, and is free from artifacts related to sectioning process (deformation and missing tissues). It enabled us to study the distribution of plaques in the entire brain in 3D. The results of this study suggest that this method may be useful for assessing treatment efficacy in mouse models of Alzheimer's disease (AD).

Alternate JournalMagn Reson Med