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Developmental regression and autism reported to the Vaccine Adverse Event Reporting System.
|Title||Developmental regression and autism reported to the Vaccine Adverse Event Reporting System.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Woo EJ, Ball R, Landa R, Zimmerman AW, Braun MM|
|Corporate Authors||VAERS Working Group|
|Journal||Autism : the international journal of research and practice|
|Date Published||2007 Jul|
We report demographic and clinical characteristics of children reported to the US Vaccine Adverse Event Reporting System (VAERS) as having autism or another developmental disorder after vaccination. We completed 124 interviews with parents and reviewed medical records for 31 children whose records contained sufficient information to evaluate the child's developmental history. Medical record review indicated that 27 of 31 (87%) children had autism/ASD and 19 (61.3%) had evidence of developmental regression (loss of social, language, or motor skills). The proportion of VAERS cases of autism with regression was greater than that reported in population-based studies, based on the subset of VAERS cases with medical record confirmation. This difference may reflect preferential reporting to VAERS of autism with regression. In other respects, the children in this study appear to be similar to other children with autism. Further research might determine whether the pathogenesis of autism with developmental regression differs from that of autism without regression.