Early development in males with Fragile X syndrome: a review of the literature.

TitleEarly development in males with Fragile X syndrome: a review of the literature.
Publication TypeJournal Article
Year of Publication2002
AuthorsKau ASM, Meyer WA, Kaufmann WE
JournalMicroscopy research and technique
Volume57
Issue3
Pagination174-8
Date Published2002 May 1
Abstract

This article reviews the current bibliographic knowledge on early neurobehavioral development and milestones in Fragile X syndrome (FraX), with emphasis on males affected by the condition. Three broad areas of early development were examined: (1) gross and fine motor, (2) speech and language, and (3) social. The result of the current review indicates very limited information on the developmental milestones in all three areas. The scarce literature on motor development shows that in FraX there is an early developmental delay. Research on speech and language demonstrates pervasive deficits in conversational skills and severe developmental delay, with increasing discrepancy between language level and chronological age in young males with FraX. Finally, deficits in social development in FraX include abnormal gaze, approach and avoidance conflict, and high incidence of autistic spectrum disorders.

Alternate JournalMicrosc. Res. Tech.