Electrosprayed Microparticles with Loaded pDNA-Calcium Phosphate Nanoparticles to Promote the Regeneration of Mature Blood Vessels.

TitleElectrosprayed Microparticles with Loaded pDNA-Calcium Phosphate Nanoparticles to Promote the Regeneration of Mature Blood Vessels.
Publication TypeJournal Article
Year of Publication2013
AuthorsGuo X, Xia T, Wang H, Chen F, Cheng R, Luo X, Li X
JournalPharmaceutical research
Date Published2013 Sep 25
Abstract

The lack of control over microvasculature formation remains a key roadblock to the therapeutic vascularization and regeneration of functional tissues. In the current study, the integration of plasmid DNA (pDNA) condensation and electrospraying technologies was proposed to promote the regeneration of mature blood vessels through injectable or infusible administration of microparticles.

DOI10.1371/journal.pone.0075464
Alternate JournalPharm. Res.