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Estrogen receptor α regulates ATM Expression through miRNAs in breast cancer.
|Title||Estrogen receptor α regulates ATM Expression through miRNAs in breast cancer.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Guo X, Yang C, Qian X, Lei T, Li Y, Shen H, Fu L, Xu B|
|Journal||Clinical cancer research : an official journal of the American Association for Cancer Research|
|Date Published||2013 Sep 15|
Estrogen receptor α (ERα) is an essential element regulating mammary gland development and it contributes to breast cancer development and progression. Most of the ER-negative breast cancers display more aggressive clinical behaviors and are resistant to antiestrogen therapies. In addition, many ER-negative tumors show insensitivity to many chemotherapeutic drugs and radiotherapy, although mechanisms underlying this phenotype are less clear.
|Alternate Journal||Clin. Cancer Res.|