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Evidence of normal cerebellar control of the vestibulo-ocular reflex (VOR) in children with high-functioning autism.
|Title||Evidence of normal cerebellar control of the vestibulo-ocular reflex (VOR) in children with high-functioning autism.|
|Publication Type||Journal Article|
|Year of Publication||2000|
|Authors||Goldberg MC, Landa R, Lasker A, Cooper L, Zee DS|
|Journal||Journal of autism and developmental disorders|
|Date Published||2000 Dec|
The effect of "tilt-suppression" on post-rotatory vestibular nystagmus was investigated to assess the function of the caudal cerebellar vermis (lobules IX and X, or nodulus and uvula) in 13 school-age children with high-functioning autism (HFA) and 10 normal controls. Tilt-suppression of the vestibulo-ocular reflex (VOR) refers to the decreasing of the duration of post-rotatory vestibular nystagmus that occurs when the head is moved out of the plane in which it was located during the previous sustained constant-velocity rotation. The participant is rotated in a vestibular chair with the head upright and then the head is tilted forward just after the chair stops rotating. Such tilt-suppression is impaired with lesions of the cerebellar nodulus and portions of the uvula. Results show that children with HFA have normal post-rotatory nystasmus with the head upright and normal attenuation of post-rotatory nystagmus induced by head tilt. These behavioral findings suggest that lobules IX and X of the cerebellum are spared in high-functioning autism.
|Alternate Journal||J Autism Dev Disord|