Evidence of normal cerebellar control of the vestibulo-ocular reflex (VOR) in children with high-functioning autism.

TitleEvidence of normal cerebellar control of the vestibulo-ocular reflex (VOR) in children with high-functioning autism.
Publication TypeJournal Article
Year of Publication2000
AuthorsGoldberg MC, Landa R, Lasker A, Cooper L, Zee DS
JournalJournal of autism and developmental disorders
Volume30
Issue6
Pagination519-24
Date Published2000 Dec
Abstract

The effect of "tilt-suppression" on post-rotatory vestibular nystagmus was investigated to assess the function of the caudal cerebellar vermis (lobules IX and X, or nodulus and uvula) in 13 school-age children with high-functioning autism (HFA) and 10 normal controls. Tilt-suppression of the vestibulo-ocular reflex (VOR) refers to the decreasing of the duration of post-rotatory vestibular nystagmus that occurs when the head is moved out of the plane in which it was located during the previous sustained constant-velocity rotation. The participant is rotated in a vestibular chair with the head upright and then the head is tilted forward just after the chair stops rotating. Such tilt-suppression is impaired with lesions of the cerebellar nodulus and portions of the uvula. Results show that children with HFA have normal post-rotatory nystasmus with the head upright and normal attenuation of post-rotatory nystagmus induced by head tilt. These behavioral findings suggest that lobules IX and X of the cerebellum are spared in high-functioning autism.

DOI10.1371/journal.pone.0050430
Alternate JournalJ Autism Dev Disord