Experience in the use of the ketogenic diet as early therapy.

TitleExperience in the use of the ketogenic diet as early therapy.
Publication TypeJournal Article
Year of Publication2005
AuthorsRubenstein JE, Kossoff EH, Pyzik PL, Vining EPG, McGrogan JR, Freeman JM
JournalJournal of child neurology
Volume20
Issue1
Pagination31-4
Date Published2005 Jan
Abstract

The ketogenic diet has traditionally been considered an anticonvulsant therapy of last resort, despite excellent efficacy and limited side effects. We hypothesized that the ketogenic diet would have similar results in patients with new-onset epilepsy. A retrospective study was conducted of patients started on the ketogenic diet since 1994. Thirteen of 460 (2.8%) patients were started on the ketogenic diet as early (zero or one prior anticonvulsant) therapy for seizures. Of those remaining on the diet, 60% (6 of 10) had a > 90% seizure reduction at 6 months and 100% (6 of 6) had a > 90% reduction at 12 months. Patients with infantile spasms were as likely to achieve > 50% seizure reduction at 6 months as patients with other seizure types (75% vs 60%; P = .6). The ketogenic diet can be a valuable therapy before epilepsy becomes intractable. In the 13 patients reported, efficacy without side effects was achieved similarly to that with patients with intractable epilepsy.

Alternate JournalJ. Child Neurol.