Fetal mechanisms in neurodevelopmental disorders.

TitleFetal mechanisms in neurodevelopmental disorders.
Publication TypeJournal Article
Year of Publication2008
AuthorsConnors SL, Levitt P, Matthews SG, Slotkin TA, Johnston MV, Kinney HC, Johnson WG, Dailey RM, Zimmerman AW
JournalPediatric neurology
Volume38
Issue3
Pagination163-76
Date Published2008 Mar
Abstract

Normal development of the central nervous system depends on complex, dynamic mechanisms with multiple spatial and temporal components during gestation. Neurodevelopmental disorders may originate during fetal life from genetic as well as intrauterine and extrauterine factors that affect the fetal-maternal environment. Fetal neurodevelopment depends on cell programs, developmental trajectories, synaptic plasticity, and oligodendrocyte maturation, which are variously modifiable by factors such as stress and endocrine disruption, exposure to pesticides such as chlorpyrifos and to drugs such as terbutaline, maternal teratogenic alleles, and premature birth. Current research illustrates how altered fetal mechanisms may affect long-term physiological and behavioral functions of the central nervous system more significantly than they affect its form, and these effects may be transgenerational. This research emphasizes the diversity of such prenatal mechanisms and the need to expand our understanding of how, when altered, they may lead to disordered development, the signs of which may not appear until long after birth.

DOI10.1203/PDR.0b013e318174e70e
Alternate JournalPediatr. Neurol.