fMRI of intrasubject variability in ADHD: anomalous premotor activity with prefrontal compensation.

TitlefMRI of intrasubject variability in ADHD: anomalous premotor activity with prefrontal compensation.
Publication TypeJournal Article
Year of Publication2008
AuthorsSuskauer SJ, Simmonds DJ, Caffo BS, Denckla MB, Pekar JJ, Mostofsky SH
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume47
Issue10
Pagination1141-50
Date Published2008 Oct
Abstract

Children with attention-deficit/hyperactivity disorder (ADHD) consistently display increased intrasubject variability (ISV) in response time across varying tasks, signifying inefficiency of response preparation compared to typically developing (TD) children. Children with ADHD also demonstrate impaired response inhibition; inhibitory deficits correlate with ISV, suggesting that similar brain circuits may underlie both processes. To better understand the neural mechanisms underlying increased ISV and inhibitory deficits in children with ADHD, functional magnetic resonance imaging was used to examine the neural correlates of ISV during Go/No-go task performance.

DOI10.1002/mrm.21712
Alternate JournalJ Am Acad Child Adolesc Psychiatry