Functional antigen-presenting leucocytes derived from human embryonic stem cells in vitro.

TitleFunctional antigen-presenting leucocytes derived from human embryonic stem cells in vitro.
Publication TypeJournal Article
Year of Publication2004
AuthorsZhan X, Dravid G, Ye Z, Hammond H, Shamblott M, Gearhart J, Cheng L
JournalLancet
Volume364
Issue9429
Pagination163-71
Date Published2004 Jul 10-16
Abstract

Differentiated cells derived from pluripotent human embryonic stem (hES) cells offer the opportunity for new transplantation therapies. However, hES cells and their differentiated progeny express highly polymorphic MHC molecules that serve as major graft rejection antigens to the immune system of allogeneic hosts. To achieve sustained engraftment of donor cells, strategies must be developed to overcome graft rejection without broadly suppressing host immunity. One approach entails induction of donor-specific immune tolerance by establishing chimeric engraftment in hosts with haemopoietic cells derived from an existing hES cell line. We aimed to develop methods to efficiently differentiate hES cells to haemopoietic cells, including immune-modulating leucocytes, a prerequisite of the tolerance induction strategies applying to hES cell-mediated transplantation.

DOI10.3897/CompCytogen.v7i3.5500
Alternate JournalLancet