Functional brain changes in presymptomatic Huntington's disease.

TitleFunctional brain changes in presymptomatic Huntington's disease.
Publication TypeJournal Article
Year of Publication2004
AuthorsReading SAJ, Dziorny AC, Peroutka LA, Schreiber M, Gourley LM, Yallapragada V, Rosenblatt A, Margolis RL, Pekar JJ, Pearlson GD, Aylward E, Brandt J, Bassett SS, Ross CA
JournalAnnals of neurology
Date Published2004 Jun

Evidence suggests early structural brain changes in individuals with the Huntington's disease (HD) genetic mutation who are presymptomatic for the movement symptoms of the illness. The aim of this study was to investigate the presence of functional brain changes in this same population using functional magnetic resonance imaging. Subjects and matched controls underwent an functional magnetic resonance imaging "interference" protocol, a task known to be mediated in part by corticostriatal circuitry. In the setting of normal cognitive performance, presymptomatic HD subjects had significantly and specifically less activation in the left anterior cingulate cortex (BA 24, 32) compared with matched controls.

Alternate JournalAnn. Neurol.