Generation of humanized animal livers using embryoid body-derived stem cell transplant.

TitleGeneration of humanized animal livers using embryoid body-derived stem cell transplant.
Publication TypeJournal Article
Year of Publication2008
AuthorsLocke JE, Sun Z, Warren DS, Sheets TP, Holzer H, Shamblott MJ, Montgomery RA, Cameron AM
JournalAnnals of surgery
Volume248
Issue3
Pagination487-93
Date Published2008 Sep
Abstract

Animal organs engineered to be chimeric for human cells could contribute significantly to the field of transplantation, including studies of human-specific diseases such as hepatitis-C, as treatment for in-born errors of metabolism, and for development of a renewable source of transplantable organs via modified xenotransplantation. We sought to use human embryoid body-derived stem cells (EBDs) to populate livers in animals for applications in transplant surgery.

DOI10.1002/mrm.21712
Alternate JournalAnn. Surg.