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Glutamate excitotoxicity mediates neuronal apoptosis after hypothermic circulatory arrest.
|Title||Glutamate excitotoxicity mediates neuronal apoptosis after hypothermic circulatory arrest.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Tseng EE, Brock MV, Lange MS, Troncoso JC, Blue ME, Lowenstein CJ, Johnston MV, Baumgartner WA|
|Journal||The Annals of thoracic surgery|
|Date Published||2010 Feb|
Prolonged hypothermic circulatory arrest results in neuronal cell death and neurologic injury. We have previously shown that hypothermic circulatory arrest causes both neuronal apoptosis and necrosis in a canine model. Inhibition of neuronal nitric oxide synthase reduced neuronal apoptosis, while glutamate receptor antagonism reduced necrosis in our model. This study was undertaken to determine whether glutamate receptor antagonism reduces nitric oxide formation and neuronal apoptosis after hypothermic circulatory arrest.
|Alternate Journal||Ann. Thorac. Surg.|