Glutamate excitotoxicity mediates neuronal apoptosis after hypothermic circulatory arrest.

TitleGlutamate excitotoxicity mediates neuronal apoptosis after hypothermic circulatory arrest.
Publication TypeJournal Article
Year of Publication2010
AuthorsTseng EE, Brock MV, Lange MS, Troncoso JC, Blue ME, Lowenstein CJ, Johnston MV, Baumgartner WA
JournalThe Annals of thoracic surgery
Volume89
Issue2
Pagination440-5
Date Published2010 Feb
Abstract

Prolonged hypothermic circulatory arrest results in neuronal cell death and neurologic injury. We have previously shown that hypothermic circulatory arrest causes both neuronal apoptosis and necrosis in a canine model. Inhibition of neuronal nitric oxide synthase reduced neuronal apoptosis, while glutamate receptor antagonism reduced necrosis in our model. This study was undertaken to determine whether glutamate receptor antagonism reduces nitric oxide formation and neuronal apoptosis after hypothermic circulatory arrest.

DOI10.1177/0883073809350221
Alternate JournalAnn. Thorac. Surg.