High-dose cyclophosphamide for refractory autoimmune hemolytic anemia.

TitleHigh-dose cyclophosphamide for refractory autoimmune hemolytic anemia.
Publication TypeJournal Article
Year of Publication2002
AuthorsMoyo VM, Smith D, Brodsky I, Crilley P, Jones RJ, Brodsky RA
JournalBlood
Volume100
Issue2
Pagination704-6
Date Published2002 Jul 15
Abstract

High-dose cyclophosphamide, without stem cell rescue, has been used successfully to treat aplastic anemia and other autoimmune disorders. To determine the safety and efficacy of high-dose cyclophosphamide among patients with severe refractory autoimmune hemolytic anemia, we treated 9 patients with cyclophosphamide (50 mg. kg(-1). d(-1) for 4 days) who had failed a median of 3 (range, 1-7) other treatments. The median hemoglobin before treatment was 6.7 g/dL (range, 5-10 g/dL). The median time to reach an absolute neutrophil count of 500/microL or greater was 16 days (range, 12-18 days). Six patients achieved complete remission (normal untransfused hemoglobin for age and sex), and none have relapsed after a median follow-up of 15 months (range, 4-29 months). Three patients achieved and continue in partial remission (hemoglobin at least 10 g/dL without transfusion support). High-dose cyclophosphamide was well tolerated and induced durable remissions in patients with severe refractory autoimmune hemolytic anemia.

Alternate JournalBlood