High-dose cyclophosphamide without stem cell transplantation in systemic lupus erythematosus.

TitleHigh-dose cyclophosphamide without stem cell transplantation in systemic lupus erythematosus.
Publication TypeJournal Article
Year of Publication2003
AuthorsPetri M, Jones RJ, Brodsky RA
JournalArthritis and rheumatism
Volume48
Issue1
Pagination166-73
Date Published2003 Jan
Abstract

High-dose chemotherapy followed by hematopoietic stem cell transplantation is increasingly being studied as a treatment for severe autoimmune disorders, such as systemic lupus erythematosus (SLE). High-dose cyclophosphamide, the foundation of virtually all conditioning regimens for stem cell transplantation, is not myeloablative; therefore, when high-dose cyclophosphamide is used alone, autografting, with its potential for reinfusing autoreactive effector cells, is not required. We undertook this study to investigate the safety and efficacy of high-dose cyclophosphamide without stem cell transplantation in refractory SLE.

Alternate JournalArthritis Rheum.