Implementation of vascular-space-occupancy MRI at 7T.

TitleImplementation of vascular-space-occupancy MRI at 7T.
Publication TypeJournal Article
Year of Publication2013
AuthorsHua J, Jones CK, Qin Q, van Zijl PCM
JournalMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
Date Published2013 Apr

Vascular-space-occupancy (VASO) MRI exploits the difference between blood and tissue T1 to null blood signal and measure cerebral blood volume changes using the residual tissue signal. VASO imaging is more difficult at higher field because of sensitivity loss due to the convergence of tissue and blood T1 values and increased contamination from blood-oxygenation-level-dependent (BOLD) effects. In addition, compared to 3T, 7T MRI suffers from increased geometrical distortions, e.g., when using echo-planar-imaging, and from increased power deposition, the latter especially problematic for the spin-echo-train sequences commonly used for VASO MRI. Third, non-steady-state blood spin effects become substantial at 7T when only a head coil is available for radiofrequency transmit. In this study, the magnetization-transfer-enhanced-VASO approach was applied to maximize tissue-blood signal difference, which boosted signal-to-noise ratio by 149% ± 13% (n = 7) compared to VASO. Second, a 3D fast gradient-echo sequence with low flip-angle (7°) and short echo-time (1.8 ms) was used to minimize the BOLD effect and to reduce image distortion and power deposition. Finally, a magnetization-reset technique was combined with a motion-sensitized-driven-equilibrium approach to suppress three types of non-steady-state spins. Our initial functional MRI results in normal human brains at 7T with this optimized VASO sequence showed better signal-to-noise ratio than at 3T.

Alternate JournalMagn Reson Med