Importance of Connexin-43 based gap junction in cirrhosis and acute-on-chronic liver failure.

TitleImportance of Connexin-43 based gap junction in cirrhosis and acute-on-chronic liver failure.
Publication TypeJournal Article
Year of Publication2013
AuthorsBalasubramaniyan V, Dhar DK, Warner AE, Li W-YV, Amiri AF, Bright B, Mookerjee RP, Davies NA, Becker DL, Jalan R
JournalJournal of hepatology
Volume58
Issue6
Pagination1194-200
Date Published2013 Jun
Abstract

In cirrhosis, superimposed inflammation often culminates in acute-on-chronic liver failure (ACLF) but the mechanism underlying this increased sensitivity is not clear. Cx43 is a ubiquitous gap junction protein that allows transmission of signals between cells at a much higher rate than the constitutively expressed gap junctions. The aims of the study were to test the hypothesis that inflammation drives the increased expression of hepatic Cx43 and to determine its role by Cx43 inhibition.

DOI10.1039/c3an00931a
Alternate JournalJ. Hepatol.