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Importance of Connexin-43 based gap junction in cirrhosis and acute-on-chronic liver failure.
|Title||Importance of Connexin-43 based gap junction in cirrhosis and acute-on-chronic liver failure.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Balasubramaniyan V, Dhar DK, Warner AE, Li W-YV, Amiri AF, Bright B, Mookerjee RP, Davies NA, Becker DL, Jalan R|
|Journal||Journal of hepatology|
|Date Published||2013 Jun|
In cirrhosis, superimposed inflammation often culminates in acute-on-chronic liver failure (ACLF) but the mechanism underlying this increased sensitivity is not clear. Cx43 is a ubiquitous gap junction protein that allows transmission of signals between cells at a much higher rate than the constitutively expressed gap junctions. The aims of the study were to test the hypothesis that inflammation drives the increased expression of hepatic Cx43 and to determine its role by Cx43 inhibition.
|Alternate Journal||J. Hepatol.|