Mapping of functional areas in the human cortex based on connectivity through association fibers.

TitleMapping of functional areas in the human cortex based on connectivity through association fibers.
Publication TypeJournal Article
Year of Publication2009
AuthorsHua K, Oishi K, Zhang J, Wakana S, Yoshioka T, Zhang W, Akhter KD, Li X, Huang H, Jiang H, van Zijl P, Mori S
JournalCerebral cortex (New York, N.Y. : 1991)
Volume19
Issue8
Pagination1889-95
Date Published2009 Aug
Abstract

In the human brain, different regions of the cortex communicate via white matter tracts. Investigation of this connectivity is essential for understanding brain function. It has been shown that trajectories of white matter fiber bundles can be estimated based on orientational information that is obtained from diffusion tensor imaging (DTI). By extrapolating this information, cortical regions associated with a specific white matter tract can be estimated. In this study, we created population-averaged cortical maps of brain connectivity for 4 major association fiber tracts, the corticospinal tract (CST), and commissural fibers. It is shown that these 4 association fibers interconnect all 4 lobes of the hemispheres. Cortical regions that were assigned based on association with the CST and the superior longitudinal fasciculus (SLF) agreed with locations of their known (CST: motor) or putative (SLF: language) functions. The proposed approach can potentially be used for quantitative assessment of the effect of white matter abnormalities on associated cortical regions.

DOI10.1002/ddrr.41
Alternate JournalCereb. Cortex