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Mapping of functional areas in the human cortex based on connectivity through association fibers.
|Title||Mapping of functional areas in the human cortex based on connectivity through association fibers.|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Hua K, Oishi K, Zhang J, Wakana S, Yoshioka T, Zhang W, Akhter KD, Li X, Huang H, Jiang H, van Zijl P, Mori S|
|Journal||Cerebral cortex (New York, N.Y. : 1991)|
|Date Published||2009 Aug|
In the human brain, different regions of the cortex communicate via white matter tracts. Investigation of this connectivity is essential for understanding brain function. It has been shown that trajectories of white matter fiber bundles can be estimated based on orientational information that is obtained from diffusion tensor imaging (DTI). By extrapolating this information, cortical regions associated with a specific white matter tract can be estimated. In this study, we created population-averaged cortical maps of brain connectivity for 4 major association fiber tracts, the corticospinal tract (CST), and commissural fibers. It is shown that these 4 association fibers interconnect all 4 lobes of the hemispheres. Cortical regions that were assigned based on association with the CST and the superior longitudinal fasciculus (SLF) agreed with locations of their known (CST: motor) or putative (SLF: language) functions. The proposed approach can potentially be used for quantitative assessment of the effect of white matter abnormalities on associated cortical regions.
|Alternate Journal||Cereb. Cortex|