Measurements of cerebral perfusion and arterial hemodynamics during visual stimulation using TURBO-TILT.

TitleMeasurements of cerebral perfusion and arterial hemodynamics during visual stimulation using TURBO-TILT.
Publication TypeJournal Article
Year of Publication2003
AuthorsHendrikse J, Lu H, van der Grond J, van Zijl PCM, Golay X
JournalMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
Volume50
Issue2
Pagination429-33
Date Published2003 Aug
Abstract

Estimation of cerebral blood flow (CBF) in functional perfusion imaging could benefit from a method capable of separating effects of arterial arrival time and trailing edge. To accomplish this, the transfer insensitive labeling technique (TILT) was combined with a train of 13 consecutive acquisitions, called TURBO-TILT. Visual activation maps obtained at 13 postlabeling delay times (TI) showed a spatial shift from regions surrounding the arterial vasculature at short TI to brain parenchyma at longer delay times. High baseline CBF and short arrival times were found for the voxels with maximum activation at short TI (<1200 ms), while CBF values (43 ml / 100 g tissue/min) and its increase upon activation (55%) at longer TI were in agreement with literature data on regional cerebral perfusion.

Alternate JournalMagn Reson Med