Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress.

TitleMitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress.
Publication TypeJournal Article
Year of Publication2003
AuthorsTeshima Y, Akao M, Li RA, Chong TH, Baumgartner WA, Johnston MV, Marbán E
JournalStroke; a journal of cerebral circulation
Volume34
Issue7
Pagination1796-802
Date Published2003 Jul
Abstract

Mitochondrial ATP-sensitive potassium (mitoK(ATP)) channels are present in the brain, and several reports have shown that mitoK(ATP) channel openers protect the brain against ischemic injury. However, the precise mechanisms of this protection are not well established. We hypothesized that mitoK(ATP) channel openers prevent apoptosis by preserving mitochondrial membrane potential.

Alternate JournalStroke