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Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress.
|Title||Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress.|
|Publication Type||Journal Article|
|Year of Publication||2003|
|Authors||Teshima Y, Akao M, Li RA, Chong TH, Baumgartner WA, Johnston MV, Marbán E|
|Journal||Stroke; a journal of cerebral circulation|
|Date Published||2003 Jul|
Mitochondrial ATP-sensitive potassium (mitoK(ATP)) channels are present in the brain, and several reports have shown that mitoK(ATP) channel openers protect the brain against ischemic injury. However, the precise mechanisms of this protection are not well established. We hypothesized that mitoK(ATP) channel openers prevent apoptosis by preserving mitochondrial membrane potential.