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Modulation of TSC-mTOR signaling on immune cells in immunity and autoimmunity.
|Title||Modulation of TSC-mTOR signaling on immune cells in immunity and autoimmunity.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Yang H, Wang X, Zhang Y, Liu H, Liao J, Shao K, Chu Y, Liu G|
|Journal||Journal of cellular physiology|
|Date Published||2014 Jan|
The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase which has a central role in the regulation of cell growth and metabolism. In the study of the mTOR signaling pathway, tuberous sclerosis complex (TSC) 1/2 complex is identified as a critical regulator of mTOR activity. TSC1/2 plays important roles for immune cell homeostasis and differentiation by negative control of mTOR signaling pathway. TSC1/2-mTOR pathway is proving to be a central point in regulating immune function of diverse immune cells. In this review, we discuss the function of TSC1/2-mTOR to direct the innate and adaptive immune cell development and function. Furthermore, we focus on the role of TSC1/2-mTOR signaling pathway in immune cell mediated diseases, especially autoimmunity.
|Alternate Journal||J. Cell. Physiol.|