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Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus.
|Title||Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Li Y, Stam FJ, Aimone JB, Goulding M, Callaway EM, Gage FH|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|Date Published||2013 May 28|
New neurons, which have been implicated in pattern separation, are continually generated in the dentate gyrus in the adult hippocampus. Using a genetically modified rabies virus, we demonstrated that molecular layer perforant pathway (MOPP) cells innervated newborn granule neurons in adult mouse brain. Stimulating the perforant pathway resulted in the activation of MOPP cells before the activation of dentate granule neurons. Moreover, activation of MOPP cells by focal uncaging of glutamate induced strong inhibition of granule cells. Together, these results indicate that MOPP cells located in the molecular layer of the dentate gyrus contribute to feed-forward inhibition of granule cells via perforant pathway activation.
|Alternate Journal||Proc. Natl. Acad. Sci. U.S.A.|