Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus.

TitleMolecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi Y, Stam FJ, Aimone JB, Goulding M, Callaway EM, Gage FH
JournalProceedings of the National Academy of Sciences of the United States of America
Volume110
Issue22
Pagination9106-11
Date Published2013 May 28
Abstract

New neurons, which have been implicated in pattern separation, are continually generated in the dentate gyrus in the adult hippocampus. Using a genetically modified rabies virus, we demonstrated that molecular layer perforant pathway (MOPP) cells innervated newborn granule neurons in adult mouse brain. Stimulating the perforant pathway resulted in the activation of MOPP cells before the activation of dentate granule neurons. Moreover, activation of MOPP cells by focal uncaging of glutamate induced strong inhibition of granule cells. Together, these results indicate that MOPP cells located in the molecular layer of the dentate gyrus contribute to feed-forward inhibition of granule cells via perforant pathway activation.

DOI10.1155/2013/405284
Alternate JournalProc. Natl. Acad. Sci. U.S.A.