MRI biosensor for protein kinase A encoded by a single synthetic gene.

TitleMRI biosensor for protein kinase A encoded by a single synthetic gene.
Publication TypeJournal Article
Year of Publication2012
AuthorsAiran RD, Bar-Shir A, Liu G, Pelled G, McMahon MT, van Zijl PCM, Bulte JWM, Gilad AA
JournalMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
Volume68
Issue6
Pagination1919-23
Date Published2012 Dec
Abstract

Protein kinases including protein kinase A (PKA) underlie myriad important signaling pathways. The ability to monitor kinase activity in vivo and in real-time with high spatial resolution in genetically specified cellular populations is a yet unmet need, crucial for understanding complex biological systems as well as for preclinical development and screening of novel therapeutics.

DOI10.1371/journal.pone.0050430
Alternate JournalMagn Reson Med