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Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury.
|Title||Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Albéri L, Chi Z, Kadam SD, Mulholland JD, Dawson VL, Gaiano N, Comi AM|
|Journal||Stroke; a journal of cerebral circulation|
|Date Published||2010 Oct|
Notch receptors (1-4) are membrane proteins that, on ligand stilumation, release their cytoplasmic domains to serve as transcription factors. Notch-2 promotes proliferation both during development and cancer, but its role in response to ischemic injury is less well understood. The purpose of this study was to understand whether Notch-2 is induced after neonatal stroke and to investigate its functional relevance.