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Osteogenesis imperfecta: questions and answers.
|Title||Osteogenesis imperfecta: questions and answers.|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Shapiro JR, Sponsellor PD|
|Journal||Current opinion in pediatrics|
|Date Published||2009 Dec|
Considerable attention has recently been focused on the pathogenesis, diagnosis and treatment of osteogenesis imperfecta. Two new genes have been defined in patients with recessive severe or lethal osteogenesis imperfecta types. Diagnostic concerns involve testing procedures, either skin biopsies or DNA analysis. Bisphosphonates have been accepted as 'standard of care' for children with osteogenesis imperfecta. However, questions remain as to the selection of patients for treatment, effectiveness in fracture prevention, which bisphosphonates should be used and the duration of treatment. Orthopedic intervention occurs on several levels: including the immediate treatment of fractures, the treatment of scoliosis and the use of intramedullary rods.
|Alternate Journal||Curr. Opin. Pediatr.|