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Performance assessment of copy number microarray platforms using a spike-in experiment.
|Title||Performance assessment of copy number microarray platforms using a spike-in experiment.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Halper-Stromberg E, Frelin L, Ruczinski I, Scharpf R, Jie C, Carvalho B, Hao H, Hetrick K, Jedlicka A, Dziedzic A, Doheny K, Scott AF, Baylin S, Pevsner J, Spencer F, Irizarry RA|
|Journal||Bioinformatics (Oxford, England)|
|Date Published||2011 Apr 15|
Changes in the copy number of chromosomal DNA segments [copy number variants (CNVs)] have been implicated in human variation, heritable diseases and cancers. Microarray-based platforms are the current established technology of choice for studies reporting these discoveries and constitute the benchmark against which emergent sequence-based approaches will be evaluated. Research that depends on CNV analysis is rapidly increasing, and systematic platform assessments that distinguish strengths and weaknesses are needed to guide informed choice.