Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia.

TitlePharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia.
Publication TypeJournal Article
Year of Publication2002
AuthorsCaparrelli DJ, Cattaneo SM, Bethea BT, Shake JG, Eberhart C, Blue ME, Marbán E, Johnston MV, Baumgartner WA, Gott VL
JournalThe Annals of thoracic surgery
Volume74
Issue3
Pagination838-44; discussion 844-5
Date Published2002 Sep
Abstract

Pharmacological openers of mitochondrial ATP-sensitive potassium (mitoKATP) channels have been shown to mimic ischemic preconditioning (IPC) in both the brain and myocardium. We hypothesized that similar endogenous mechanisms exist in the spinal cord and that diazoxide, a potent mitoKATP opener, could reduce neurologic injury after aortic cross-clamping in a model of spinal cord ischemia.

Alternate JournalAnn. Thorac. Surg.