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Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss.
|Title||Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Mielke MM, Haughey NJ, Ratnam Bandaru VV, Schech S, Carrick R, Carlson MC, Mori S, Miller MI, Ceritoglu C, Brown T, Albert M, Lyketsos CG|
|Journal||Alzheimer's & dementia : the journal of the Alzheimer's Association|
|Date Published||2010 Sep|
A blood-based biomarker of Alzheimer's disease (AD) would be superior to cerebrospinal fluid (CSF) and neuroimaging measures in terms of cost, invasiveness, and feasibility for repeated measures. We previously reported that blood ceramides varied in relation to timing of memory impairment in a population-based study. The present objective was to examine whether plasma ceramides varied by AD severity in a well-characterized clinic sample and were associated with cognitive decline and hippocampal volume loss over 1 year.
|Alternate Journal||Alzheimers Dement|