Plk1-dependent microtubule dynamics promotes androgen receptor signaling in prostate cancer.

TitlePlk1-dependent microtubule dynamics promotes androgen receptor signaling in prostate cancer.
Publication TypeJournal Article
Year of Publication2013
AuthorsHou X, Li Z, Huang W, Li J, Staiger C, Kuang S, Ratliff T, Liu X
JournalThe Prostate
Volume73
Issue12
Pagination1352-63
Date Published2013 Sep
Abstract

The androgen receptor (AR) signaling continues to be essential in castrate-resistant prostate cancer (CRPC). Taxel-based chemotherapy is the current standard treatment for CRPC patients. Unfortunately, almost all patients eventually develop resistance toward this chemotherapy. Significantly, it was recently found that the anti-tumor effect of paclitaxel in CRPC is due to its inhibition of AR activity via its inhibition of microtubule dynamics. Polo-like kinase 1 (Plk1), a critical regulator in many cell cycle events, is elevated in prostate cancer (PCa) and linked to tumor grades. Of note, we have previously shown that Plk1 phosphorylates CLIP-170 and p150(Glued) , two important regulators of microtubule dynamics.

DOI10.3980/j.issn.2222-3959.2013.03.08
Alternate JournalProstate