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Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery.
|Title||Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery.|
|Publication Type||Journal Article|
|Year of Publication||2002|
|Authors||Goto S, Xue R, Sugo N, Sawada M, Blizzard KK, Poitras MF, Johns DC, Dawson TM, Dawson VL, Crain BJ, Traystman RJ, Mori S, Hurn PD|
|Journal||Stroke; a journal of cerebral circulation|
|Date Published||2002 Apr|
Poly(ADP-ribose) polymerase (PARP-1; Enzyme Commission 2.4.30) is a nuclear DNA repair enzyme that mediates early neuronal ischemic injury. Using novel 3-dimensional, fast spin-echo-based diffusion-weighted imaging, we compared acute (21 hours) and long-term (3 days) ischemic volume after middle cerebral artery (MCA) occlusion in PARP-1-null mutants (PARP-/-) versus genetically matched wild-type mice (WT mice). PARP-/- mice were also treated with viral transfection of wild-type PARP-1 to determine whether protection from MCA occlusion is lost with restoration of the gene product.