Practical data acquisition method for human brain tumor amide proton transfer (APT) imaging.

TitlePractical data acquisition method for human brain tumor amide proton transfer (APT) imaging.
Publication TypeJournal Article
Year of Publication2008
AuthorsZhou J, Blakeley JO, Hua J, Kim M, Laterra J, Pomper MG, van Zijl PCM
JournalMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
Date Published2008 Oct

Amide proton transfer (APT) imaging is a type of chemical exchange-dependent saturation transfer (CEST) magnetic resonance imaging (MRI) in which amide protons of endogenous mobile proteins and peptides in tissue are detected. Initial studies have shown promising results for distinguishing tumor from surrounding brain in patients, but these data were hampered by magnetic field inhomogeneity and a low signal-to-noise ratio (SNR). Here a practical six-offset APT data acquisition scheme is presented that, together with a separately acquired CEST spectrum, can provide B(0)-inhomogeneity corrected human brain APT images of sufficient SNR within a clinically relevant time frame. Data from nine brain tumor patients at 3T shows that APT intensities were significantly higher in the tumor core, as assigned by gadolinium-enhancement, than in contralateral normal-appearing white matter (CNAWM) in patients with high-grade tumors. Conversely, APT intensities in tumor were indistinguishable from CNAWM in patients with low-grade tumors. In high-grade tumors, regions of increased APT extended outside of the core into peripheral zones, indicating the potential of this technique for more accurate delineation of the heterogeneous areas of brain cancers.

Alternate JournalMagn Reson Med