Prenatal antecedents of newborn neurological maturation.

TitlePrenatal antecedents of newborn neurological maturation.
Publication TypeJournal Article
Year of Publication2010
AuthorsDiPietro JA, Kivlighan KT, Costigan KA, Rubin SE, Shiffler DE, Henderson JL, Pillion JP
JournalChild development
Volume81
Issue1
Pagination115-30
Date Published2010 Jan-Feb
Abstract

Fetal neurobehavioral development was modeled longitudinally using data collected at weekly intervals from 24 to 38 weeks gestation in a sample of 112 healthy pregnancies. Predictive associations between 3 measures of fetal neurobehavioral functioning and their developmental trajectories to neurological maturation in the first weeks after birth were examined. Prenatal measures included fetal heart rate (FHR) variability, fetal movement, and coupling between fetal motor activity and heart rate patterning; neonatal outcomes include a standard neurologic examination (n = 97) and brainstem auditory evoked potential (BAEP; n = 47). Optimality in newborn motor activity and reflexes was predicted by fetal motor activity, FHR variability, and somatic-cardiac coupling predicted BAEP parameters. Maternal pregnancy-specific psychological stress was associated with accelerated neurologic maturation.

DOI10.1089/scd.2009.0326
Alternate JournalChild Dev