Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology.

TitlePrenatal interaction of mutant DISC1 and immune activation produces adult psychopathology.
Publication TypeJournal Article
Year of Publication2010
AuthorsAbazyan B, Nomura J, Kannan G, Ishizuka K, Tamashiro KL, Nucifora F, Pogorelov V, Ladenheim B, Yang C, Krasnova IN, Cadet JL, Pardo C, Mori S, Kamiya A, Vogel MW, Sawa A, Ross CA, Pletnikov MV
JournalBiological psychiatry
Volume68
Issue12
Pagination1172-81
Date Published2010 Dec 15
Abstract

Gene-environment interactions (GEI) are involved in the pathogenesis of mental diseases. We evaluated interaction between mutant human disrupted-in-schizophrenia 1 (mhDISC1) and maternal immune activation implicated in schizophrenia and mood disorders.

DOI10.1097/CCM.0b013e31825457b8
Alternate JournalBiol. Psychiatry