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Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart.
|Title||Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart.|
|Publication Type||Journal Article|
|Year of Publication||2005|
|Authors||Mao R, Wang X, Spitznagel EL, Frelin LP, Ting JC, Ding H, Kim J-whan, Ruczinski I, Downey TJ, Pevsner J|
Down syndrome, caused by trisomic chromosome 21, is the leading genetic cause of mental retardation. Recent studies demonstrated that dosage-dependent increases in chromosome 21 gene expression occur in trisomy 21. However, it is unclear whether the entire transcriptome is disrupted, or whether there is a more restricted increase in the expression of those genes assigned to chromosome 21. Also, the statistical significance of differentially expressed genes in human Down syndrome tissues has not been reported.
|Alternate Journal||Genome Biol.|