Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart.

TitlePrimary and secondary transcriptional effects in the developing human Down syndrome brain and heart.
Publication TypeJournal Article
Year of Publication2005
AuthorsMao R, Wang X, Spitznagel EL, Frelin LP, Ting JC, Ding H, Kim J-whan, Ruczinski I, Downey TJ, Pevsner J
JournalGenome biology
Volume6
Issue13
PaginationR107
Date Published2005
Abstract

Down syndrome, caused by trisomic chromosome 21, is the leading genetic cause of mental retardation. Recent studies demonstrated that dosage-dependent increases in chromosome 21 gene expression occur in trisomy 21. However, it is unclear whether the entire transcriptome is disrupted, or whether there is a more restricted increase in the expression of those genes assigned to chromosome 21. Also, the statistical significance of differentially expressed genes in human Down syndrome tissues has not been reported.

Alternate JournalGenome Biol.