Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: a pilot investigation comparing treatment responders and non-responders.

TitleProton magnetic resonance spectroscopy in obsessive-compulsive disorder: a pilot investigation comparing treatment responders and non-responders.
Publication TypeJournal Article
Year of Publication2007
AuthorsMohamed MA, Smith MA, Schlund MW, Nestadt G, Barker PB, Hoehn-Saric R
JournalPsychiatry research
Volume156
Issue2
Pagination175-9
Date Published2007 Nov 15
Abstract

Proton magnetic resonance spectroscopic imaging was performed to compare brain metabolism in patients with obsessive-compulsive OCD. Evaluation was done on responders and non-responders to pharmacotherapy and on healthy controls. The results showed significantly lower NAA/Cr ratios in the right basal ganglia in non-responders than in responders or in controls and higher Cho/Cr ratios in the right thalamus in non-responders than responders. Abnormal neuronal metabolism in the right basal ganglia and right thalamus may be indicating lack of response to treatment to selective serotonin reuptake inhibitor.

Alternate JournalPsychiatry Res