Quantitative description of the asymmetry in magnetization transfer effects around the water resonance in the human brain.

TitleQuantitative description of the asymmetry in magnetization transfer effects around the water resonance in the human brain.
Publication TypeJournal Article
Year of Publication2007
AuthorsHua J, Jones CK, Blakeley J, Smith SA, van Zijl PCM, Zhou J
JournalMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
Volume58
Issue4
Pagination786-93
Date Published2007 Oct
Abstract

Magnetization transfer (MT) imaging provides a unique method of tissue characterization by capitalizing on the interaction between solid-like tissue components and bulk water. We used a continuous-wave (CW) MT pulse sequence with low irradiation power to study healthy human brains in vivo at 3 T and quantified the asymmetry of the MT effects with respect to the water proton frequency. This asymmetry was found to be a difference of approximately a few percent from the water signal intensity, depending on both the RF irradiation power and the frequency offset. The experimental results could be quantitatively described by a modified two-pool MT model extended with a shift contribution for the semisolid pool with respect to water. For white matter, this shift was fitted to be 2.34 +/- 0.17 ppm (N = 5) upfield from the water signal.

Alternate JournalMagn Reson Med