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Quantitative description of the asymmetry in magnetization transfer effects around the water resonance in the human brain.
|Title||Quantitative description of the asymmetry in magnetization transfer effects around the water resonance in the human brain.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Hua J, Jones CK, Blakeley J, Smith SA, van Zijl PCM, Zhou J|
|Journal||Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine|
|Date Published||2007 Oct|
Magnetization transfer (MT) imaging provides a unique method of tissue characterization by capitalizing on the interaction between solid-like tissue components and bulk water. We used a continuous-wave (CW) MT pulse sequence with low irradiation power to study healthy human brains in vivo at 3 T and quantified the asymmetry of the MT effects with respect to the water proton frequency. This asymmetry was found to be a difference of approximately a few percent from the water signal intensity, depending on both the RF irradiation power and the frequency offset. The experimental results could be quantitatively described by a modified two-pool MT model extended with a shift contribution for the semisolid pool with respect to water. For white matter, this shift was fitted to be 2.34 +/- 0.17 ppm (N = 5) upfield from the water signal.
|Alternate Journal||Magn Reson Med|