Rational design of multifunctional upconversion nanocrystals/polymer nanocomposites for cisplatin (IV) delivery and biomedical imaging.

TitleRational design of multifunctional upconversion nanocrystals/polymer nanocomposites for cisplatin (IV) delivery and biomedical imaging.
Publication TypeJournal Article
Year of Publication2013
AuthorsMa P'an, Xiao H, Li X, Li C, Dai Y, Cheng Z, Jing X, Lin J
JournalAdvanced materials (Deerfield Beach, Fla.)
Volume25
Issue35
Pagination4898-905
Date Published2013 Sep 20
Abstract

By combining upconversion nanoparticles with the cisplatin (IV) prodrug we have demonstrated that a stable and multifunctional drug delivery system can be designed that will both reduce the drawbacks of cisplatin and give insight in to its in vitro/in vivo imaging. The up/down-conversion fluorescence are detectable and show obvious co-localization, demonstrating that the nanoparticles are rather stable inside cells and retain the UCNPs and block copolymer.

DOI10.1093/ajh/hpt119
Alternate JournalAdv. Mater. Weinheim