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Rational design of multifunctional upconversion nanocrystals/polymer nanocomposites for cisplatin (IV) delivery and biomedical imaging.
|Title||Rational design of multifunctional upconversion nanocrystals/polymer nanocomposites for cisplatin (IV) delivery and biomedical imaging.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Ma P'an, Xiao H, Li X, Li C, Dai Y, Cheng Z, Jing X, Lin J|
|Journal||Advanced materials (Deerfield Beach, Fla.)|
|Date Published||2013 Sep 20|
By combining upconversion nanoparticles with the cisplatin (IV) prodrug we have demonstrated that a stable and multifunctional drug delivery system can be designed that will both reduce the drawbacks of cisplatin and give insight in to its in vitro/in vivo imaging. The up/down-conversion fluorescence are detectable and show obvious co-localization, demonstrating that the nanoparticles are rather stable inside cells and retain the UCNPs and block copolymer.
|Alternate Journal||Adv. Mater. Weinheim|