Representation of internal models of action in the autistic brain.

TitleRepresentation of internal models of action in the autistic brain.
Publication TypeJournal Article
Year of Publication2009
AuthorsHaswell CC, Izawa J, Dowell LR, Mostofsky SH, Shadmehr R
JournalNature neuroscience
Date Published2009 Aug

Children with autism spectrum disorder (ASD) have deficits in motor control, imitation and social function. Does a dysfunction in the neural basis of representing internal models of action contribute to these problems? We measured patterns of generalization as children learned to control a novel tool and found that the autistic brain built a stronger than normal association between self-generated motor commands and proprioceptive feedback; furthermore, the greater the reliance on proprioception, the greater the child's impairments in social function and imitation.

Alternate JournalNat. Neurosci.