Role of cyclic nucleotides in fetal hemoglobin induction in cultured CD34+ cells.

TitleRole of cyclic nucleotides in fetal hemoglobin induction in cultured CD34+ cells.
Publication TypeJournal Article
Year of Publication2006
AuthorsKeefer JR, Schneidereith TA, Mays A, Purvis SH, Dover GJ, Smith KD
JournalExperimental hematology
Volume34
Issue9
Pagination1151-61
Date Published2006 Sep
Abstract

In vivo, several drugs have been shown to increase fetal hemoglobin (HbF), including 5-azacytidine (AZA), sodium butyrate (SB), and hydroxyurea (HU). Studies in K562 cells suggest that cyclic guanosine monophosphate (cGMP) is required for HbF induction; however, the role of cyclic nucleotides in HbF induction in primary erythroid cultures has not been established.

Alternate JournalExp. Hematol.